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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EGFR All Species: 26.67
Human Site: S768 Identified Species: 53.33
UniProt: P00533 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P00533 NP_005219.2 1210 134277 S768 D E A Y V M A S V D N P H V C
Chimpanzee Pan troglodytes XP_519102 1210 134401 S768 D E A Y V M A S V D N P H V C
Rhesus Macaque Macaca mulatta XP_001107305 1120 124266 P691 Q E R E L V E P L T P S G E A
Dog Lupus familis XP_533073 1595 175523 S1156 D E A Y V M A S V D N P H V C
Cat Felis silvestris
Mouse Mus musculus Q01279 1210 134835 S770 D E A Y V M A S V D N P H V C
Rat Rattus norvegicus Q62956 1308 146940 S774 D E A L I M A S V D H P H L V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507339 1187 132966 S743 D E A Y V M A S V D N P H V C
Chicken Gallus gallus P13387 703 77409 L274 C K D T C P P L V L Y N P T T
Frog Xenopus laevis Q91694 985 109711 S555 L L V S V A G S I V L V V I L
Zebra Danio Brachydanio rerio NP_919405 1191 132465 I758 S P K A N K E I M D E A Y V M
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P04412 1426 159700 S994 R E A Y I M A S E E H V N L L
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P24348 1323 150493 V825 R M V I I G S V L F G F A V M
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.3 90.3 69.5 N.A. 90.5 49.4 N.A. 82.1 42.4 21.8 62.4 N.A. 35.2 N.A. 27.7 N.A.
Protein Similarity: 100 99.6 91.4 72.6 N.A. 95 64.6 N.A. 88.4 48.2 37.4 74 N.A. 51.1 N.A. 46.7 N.A.
P-Site Identity: 100 100 6.6 100 N.A. 100 66.6 N.A. 100 6.6 13.3 13.3 N.A. 40 N.A. 6.6 N.A.
P-Site Similarity: 100 100 26.6 100 N.A. 100 86.6 N.A. 100 13.3 26.6 26.6 N.A. 73.3 N.A. 26.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 59 9 0 9 59 0 0 0 0 9 9 0 9 % A
% Cys: 9 0 0 0 9 0 0 0 0 0 0 0 0 0 42 % C
% Asp: 50 0 9 0 0 0 0 0 0 59 0 0 0 0 0 % D
% Glu: 0 67 0 9 0 0 17 0 9 9 9 0 0 9 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 9 0 9 0 0 0 % F
% Gly: 0 0 0 0 0 9 9 0 0 0 9 0 9 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 17 0 50 0 0 % H
% Ile: 0 0 0 9 25 0 0 9 9 0 0 0 0 9 0 % I
% Lys: 0 9 9 0 0 9 0 0 0 0 0 0 0 0 0 % K
% Leu: 9 9 0 9 9 0 0 9 17 9 9 0 0 17 17 % L
% Met: 0 9 0 0 0 59 0 0 9 0 0 0 0 0 17 % M
% Asn: 0 0 0 0 9 0 0 0 0 0 42 9 9 0 0 % N
% Pro: 0 9 0 0 0 9 9 9 0 0 9 50 9 0 0 % P
% Gln: 9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 17 0 9 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 9 0 0 9 0 0 9 67 0 0 0 9 0 0 0 % S
% Thr: 0 0 0 9 0 0 0 0 0 9 0 0 0 9 9 % T
% Val: 0 0 17 0 50 9 0 9 59 9 0 17 9 59 9 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 50 0 0 0 0 0 0 9 0 9 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _